The No. 16 Louisville Cardinals face the Virginia Tech Hokies on Saturday, Nov. 1, 2025 at Lane Stadium in Blacksburg, Va.

The Virginia Tech Hokies won their third game of the season on Friday night in thrilling fashion, defeating the California Golden Bears 42-34 in double overtime. Quarterback Kyron Drones accounted for five touchdowns in the win, as the Hokies rushed for 357 yards.

The No. 16 Louisville Cardinals and the Virginia Tech Hokies meet on Saturday in an ACC matchup that will be televised nationally. The game will feature a Louisville team that is trying to stay in the ACC championship race and a Virginia Tech team trying to make a bowl game.

Isaac Brown rushed for 130 yards and a touchdown before leaving late with a leg injury and Keyjuan Brown scored twice in the second half to lift No. 16 Louisville to a 28-16 victory over Virginia Tech.

Preview the Week 9 NCAA football matchup between the Virginia Tech Hokies and California Golden Bears with a prediction, pick, odds and more.

Only a quartet of contests remain for Virginia Tech football in its 2025 campaign. Through a turbulent campaign, the Hokies have notched three wins and will need to claim as many over the next month to qualify for a bowl game this season.

After several close ACC wins this season for unbeaten Georgia Tech, the dam finally broke defensively during Saturday night's 48-36 loss at NC State, the second stunner in conference play to highlight Week 10 following SMU's overtime triumph over Miami.

College football Week 10 odds, picks, predictions, TV channel, streaming for Virginia Cavaliers vs California Golden Bears ACC game Saturday, Nov. 1.