Interaction specificity is a required feature of biological networks and a necessary characteristic of protein or small-molecule reagents and therapeutics. The ability to alter or inhibit protein ...

Computational protein design—the automated search for amino acid sequences with defined three-dimensional structures—opens exciting possibilities for the engineering of biomolecules with desired ...

Dynamic interactions involving biomolecules drive and regulate all biological processes, making interaction analysis a key area of academic and industrial research and development. A variety of ...

A team of scientists led by Patrick Barth at EPFL have developed advanced computational tools that aim to shift the scale of ...