The number of replication origin sequences in the genome does not change during the lifespan of an organism, but the number of active origins does vary according to the developmental stage. In the ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 40 (October 4, 2022), pp. 1-12 (12 pages) Eukaryotic chromosomes are organized into structural and ...

Today, we’re going to talk about genomes. Strictly speaking, genomes have two crucial functions: they must exist (to store genetic information and enable that information to be used by the cell), and ...

Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease and ...

DNA replication origins serve as sites of replicative helicase loading. In all eukaryotes, the six-subunit origin recognition complex (Orc1-6; ORC) recognizes the replication origin. During late ...

After decades of mystery, scientists have finally figured out the structure of a key herpes virus protein that is vital for ...

Case Western Reserve University researchers studying human prions—misfolded proteins that cause lethal and incurable diseases—have, for the first time, identified surface features responsible for the ...

As cells divide, they must copy all of their chromosomes once and only once, or chaos would ensue. How do they do it? By Amber Dance/Knowable Magazine Published Jul 7, 2023 6:00 PM EDT This article ...

Breakthrough cryo-EM structures expose multiple drug targets in an essential HSV-1 replication protein.An international ...

An international research team has determined the first high-resolution structures of the herpes simplex virus origin-binding protein (OBP), a critical component of viral DNA replication that has ...